Compared with the EGFRwt group, in the EGFRmt group, there was a higher percentage of lymph node metastasis as the main style of cancer progression, papillary pattern predominance, and micropapillary pattern presence.18,19) However, EGFRmt lung cancer has been linked to better surgical outcome than EGFRwt lung cancer.20–23) It is well established that the lepidic histological subtype is the major component of lung adenocarcinomas harboring EGFR mutations. This evidence concerns the gene EGFR and lung adenocarcinoma.