While we found no evidence of either LdSET7 or LdSET29 being secreted into the host cytosol, it is possible that these proteins regulate NADPH Oxidase Complex formation indirectly by targeting one or more parasite membrane proteins, which include a metalloprotease (gp63) and a kinase (protein kinase C) that have both been found to moderate host-Leishmania interactions post-infection (reviewed in (38)). The gene discussed is LMLN; the disease is infection.