However, over the last two decades, other families of innate immune receptors such as Nod-like receptors (NLRs) and inflammasomes as well as cyclic GMP-AMP synthase (cGAS), retinoic acid-inducible gene I receptor (RIGI) and C-type lectin receptors have also been implicated in sensing Plasmodium infection and been involved both in host resistance to infection and the pathogenesis of malaria [4,5,13,14]. This evidence concerns the gene CGAS and infection.