CD4 and HIV-1 infection: As a consensus definition, we propose to use the following selection criteria: mean viral load > 10,000 HIV RNA copies/mL (starting six months after date of seroconversion/diagnose) and CD4+ T cell decay rates < 10% cells/μl/year for a minimum period of 4 years since diagnosis of HIV-1 infection or the estimated seroconversion date.140