Quantitative analysis elucidated a significant reduction in perineural integrity within PDAC tissues compared to CP and NP (CP: 58.46 ± 18.35 % vs. PCa: 36.50 ± 13.14 %, p = 0.0065; NP: 77.95 ± 8.2 % vs. PCa: 36.50 ± 13.14 %, p < 0.0001; Fig. 1B). This evidence concerns the gene CP and posterior cortical atrophy.