S100A1 and cardiovascular disorder: Their abnormalupregulation may increase the risk of cardiovascular diseases suchas atherosclerosis and pericarditis.40,41 Moreover,we found significant expression changes in two key proteins involvedin mitochondrial function: S100A1 (FC = 0.04, p = 0.036) and ATPIF1(FC = 2.74, p = 0.015).