Because tumor-associated macrophages (TAMs), together with myeloid-derived suppressor cells (MDSCs) and Tregs and B cells, are the main sources of IL-10 in the tumor microenvironment and contribute to the abolishment of the cytotoxic T cell response (35), we hypothesized that S3QEL 1.2 could have a beneficial effect through the dampening of tumor-driven immunotolerance mediated by IL-10. This evidence concerns the gene IL10 and neoplasm.