USP5 has been claimed to act as a recycling DUB, required to maintain cellular ubiquitin homeostasis (22), which was later confirmed by inactivation of Usp5 homologs in Saccharomyces cerevisiae (23) and Dictyostelium discoideum (24), and by short hairpin RNA (shRNA)–mediated knockdown of Usp5 in ARN8 melanoma cells (25). The gene discussed is USP5; the disease is melanoma.