TIMP4 and coronary artery disorder: The gene region proposed was in the range of D3S1263–D3S3594.16 It comprises the SLC6A11, SLC6A1, HRH1, and ATG7 genes, but excludes other possible CHD candidates suggested before, such as PMCA2, TIMP4, and SEC13R. 16 Thus, assuming gene non-penetrance in cases without CHDs, the authors concluded that it would be likely that the haploinsufficiency of one or more genes in the critical interval could cause failures in cardiac development.