CD8A and mycosis fungoides: Diagnosing HMF is challenging due to its clinical-pathological and molecular characteristics;9 multiple biopsies are sometimes necessary to confirm it.21 HMF has distinctive histopathological and molecular features compared to classic MF in general, such as a higher frequency of CD8+ lymphocytes in the epidermis,6 in addition to atypical and enlarged lymphocytes, with a halo and convoluted nucleus, contrasting with the mild to moderate dermal infiltrate.22 The first-line treatment for this variant is phototherapy.23