Glucagon-like peptide-1 (GLP-1) is a peptide hormone stimulatinga decrease in blood glucose levels and thus is of crucial importanceas a therapeutic agent for the treatment of type 2 diabetes and obesity.However, native GLP-1 has a half-life in vivo ofcirca 2 min, which results from rapid degradation by the dipeptidylpeptidase-4 enzyme.14,15 It was shown that lipidationof GLP-1 can increase its half-life in vivo to hoursor even days. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.