Additionally, in JAKi-treated KPCSmad4-KO PDAC, macrophages, apCAFs and FOXP3+ T regulatory T cells were reduced, and non-exhausted total T cells and CD8+ T cells were increased (59), which may contribute to impairing tumor growth (Supplementary Fig. 8N and 8Q-U). Here, FOXP3 is linked to neoplasm.