In this study, we found that the combination of CB and AKK in IBD mice can more significantly reduce the levels of MDA and MPO in the serum or colon of mice than the single intervention of CB or AKK, indicating that the combination of CB and AKK can better alleviate the oxidative stress damage caused by DSS-induced colitis in IBD mice and improve the disrupted intestinal barrier. The gene discussed is MPO; the disease is colitis.