USP7 (ubiquitin‐specific protease 7) plays important roles in cancer progression by deubiquitinating and stabilizing various oncogenic proteins like MDM2, FOXP3, and PTEN, thereby emerged as a promising therapeutic target.[33] In colon cancers harboring APC mutations, USP7 acts also as a tumor‐specific Wnt activator by promoting the deubiquitination and stabilization of β‐catenin.[34] Deletion of USP7 in colon cancers inhibits Wnt activation by restoring β‐catenin ubiquitination, facilitating differentiation and suppressing tumor growth. Here, MDM2 is linked to colonic neoplasm.