USP7 and colonic neoplasm: Further analysis was conducted by assessing the changes in enrichment scores for normal colon signatures in colon cancer cell lines following genetic perturbations, using data from the LINCS L1000 database.[20] This revealed that the inhibition of several genes, such as APBB2, BDH1, and USP7, substantially enhances the normal colon signature within cancer cell lines (Figure 5c).