Further analysis was conducted by assessing the changes in enrichment scores for normal colon signatures in colon cancer cell lines following genetic perturbations, using data from the LINCS L1000 database.[20] This revealed that the inhibition of several genes, such as APBB2, BDH1, and USP7, substantially enhances the normal colon signature within cancer cell lines (Figure 5c). This evidence concerns the gene USP7 and malignant colon neoplasm.