These results suggest that USP7 exhibits anti‐cancer properties in colon cancer, which is consistent with our DepMap analysis result (Figure 5b) and previous experimental findings.[33] Next, Gene Ontology (GO) analysis of positive DEGs upon USP7 knockdown revealed its significant association with the pathways implicated in normal colon epithelial cells and the genes related to the negative regulation of cell cycle and cell proliferation (Figure 5j), consistent with the previous L1000 analysis results (Figure 5c). Here, USP7 is linked to cancer.