Previous studies have suggested that lymphocytes infiltrating into the tumor, such as tumor-associated macrophages and regulatory T cells, can mediate the immunosuppressive TME and help the tumor cells to achieve immune escape, thereby promoting the malignant progression of the tumor.27,28 Considering that ITGBL1 was a new immunomodulator that expedited melanoma progression by suppressing the cytotoxicity of NK cells, we further analyzed the relationship between ITGBL1 and immune infiltration in COAD cells. Here, ITGBL1 is linked to neoplasm.