ITGBL1 and melanoma: Previous studies have suggested that lymphocytes infiltrating into the tumor, such as tumor-associated macrophages and regulatory T cells, can mediate the immunosuppressive TME and help the tumor cells to achieve immune escape, thereby promoting the malignant progression of the tumor.27,28 Considering that ITGBL1 was a new immunomodulator that expedited melanoma progression by suppressing the cytotoxicity of NK cells, we further analyzed the relationship between ITGBL1 and immune infiltration in COAD cells.