Meanwhile, GEPIA database analysis displayed that ITGBL1 expression was positively related to M2-type macrophage markers (MRC1, CD163, IL-10, and TGFB1) and programmed death ligand 1 (PD-L1; also known as CD274) in COAD (Figure 4B). The gene discussed is CD274; the disease is colon adenocarcinoma.