An extensive panel of antioxidant enzyme genes are considered as NRF2 targeted genes, and the activation of NRF2 is regarded as an effective strategy against oxidative stress.[11, 12] Consequently, NRF2 activators, such as SFN and Bixin, exhibit great therapeutic action against various oxidative stress‐related diseases.[13] In contrast, accumulating evidences indicate that NRF2 signaling pathway acts as a functional driver of cancer progression and metastasis, and the activation of NRF2 and its target genes promote drug resistance to chemotherapy in cancer treatment. Here, SFN is linked to cancer.