The treatment with GH significantly increased the protein level of NRF2 and promoted the transcription of NRF2 target gene, SLC7A11, which influenced glutathione (GSH) metabolism and NADP+‐NADPH metabolism processes in HCC, and promoted the formation of disulfide bonds between different cytoskeleton proteins as well as disulfidptosis ultimately. Here, SLC7A11 is linked to hepatocellular carcinoma.