AKT1 and hepatocellular carcinoma: The genes associated with hepatocarcinogenesis were summarized using DisGeNET database (Table S2, Supporting Information), and 13 potential bioavailable targets (including the key autophagy regulator MTOR) of GH were overlapped with hepatocarcinogenesis genes (Figure 1H), indicating that GH treatment could be considered as a novel approach against HCC, and PI3K/Akt/mTOR and autophagy could be potential mechanism.