TYP can downregulate the abundance of Erysipelatoclostridium, which appears to be more prevalent in inflammatory bowel disease[81] and obesity.[82] In addition, the single bacterial experiment results indicated that the metabolic rate of TYP by B. thetaiotaomicron and B. uniformis is much higher than that of mixed bacteria. The gene discussed is DUSP4; the disease is inflammatory bowel disease.