DUSP4 and obesity due to melanocortin 4 receptor deficiency: TYP can downregulate the abundance of Erysipelatoclostridium, which appears to be more prevalent in inflammatory bowel disease[81] and obesity.[82] In addition, the single bacterial experiment results indicated that the metabolic rate of TYP by B. thetaiotaomicron and B. uniformis is much higher than that of mixed bacteria.