AKR1C3 and cancer: Among them, some reported overexpressed proteins in chronic myelogenous leukemia (CML) or potential targets for cancer treatments were observed to exhibit downregulation in cluster H2 (Figure 5c), such as HSP90AA1[55] and HSP90AB1[56] of HSP90 family, AKR1C3,[57] HMGA1,[58] CRKL,[59] EIF5A,[60] and MCM7.[61] Moreover, the Gene Ontology (GO) enrichment analysis was performed based on these differential proteins.