The model consisting of PSAD, PSA and the base variables predicted prostate cancer mortality (c-statistic 0.781) significantly better than either the base variables alone (c-statistic 0.737; likelihood-ratio test, P = 0.003) or the base variables and PSA (c-statistic 0.765; likelihood-ratio test, P = 0.039).<h4>Conclusion</h4>Prostate cancer mortality after a benign systematic TRUS-guided biopsy is low. The gene discussed is KLK3; the disease is Familial prostate cancer.