Patients with loss‐of‐function mutations in WAC were first identified as having Desanto‐Shinawi syndrome in 2015, which is characterized by a neurocognitive phenotype and facial dysmorphism.[16] Interestingly, all patients with Desanto‐Shinawi syndrome and loss‐of‐function mutations in WAC appear to have lost the CC domain of WAC,[30] which strengthens our hypothesis that phase‐separated characteristics play an important role in nuclear biological functions. Here, WAC is linked to DeSanto-Shinawi syndrome.