WAC and DeSanto-Shinawi syndrome: WAC is a regulator of multiple cellular functions, including histone H2B ubiquitination and transcription[13] and timely entry into mitosis.[14] In addition, WAC‐mediated H2B ubiquitination regulates plasma cell differentiation.[15] Mutations in the WAC gene cause DeSanto‐Shinawi syndrome, a recognizable genetic syndrome characterized by developmental delay, hypotonia, and dysmorphic features,[16] which suggests that WAC plays essential roles in the skeletal and nervous systems.