CREB1 and cancer: MAPK14, a member of the p38MAPK family, plays a role in stress responses and has been implicated in a variety of pathological conditions including inflammation, aberrant apoptosis, and cancer metastasis.[28] It has been demonstrated that inhibiting p38MAPK activity with regorafenib represses M2 polarization of macrophages, which in turn suppresses p38MAPK‐regulated Creb1 phosphorylation to downregulate Klf4 transcription.