As an inflammation modulator, SLURP1 inhibits the TNF‐α‐induced upregulation of inflammatory cytokines by suppressing NF‐κB nuclear translocation.[26] Recent research has demonstrated that SLURP1 not only inhibits cell proliferation but also has the potential to arrest the colon cancer cell cycle at the G1/S interface. Here, SLURP1 is linked to malignant colon neoplasm.