Once MAPK14 becomes activated, it can translocate into the nucleus and phosphorylate many substrates on Ser or Thr residues, such as p53, Elk, Creb1, etc, leading to the regulation of gene transcription.[10] The function of MAPK14 in CRC is controversial.[11] Mice with MAPK14‐deficient intestinal epithelial cells are more susceptible to colitis‐associated colon tumorigenesis. The gene discussed is MAPK14; the disease is colitis.