SLURP1 belongs to the LY6/PLAUR protein family and serves as an autocrine or paracrine factor that regulates the growth, differentiation, and migration of keratinocytes.[14] SLURP1 can inhibit the proliferation of colon cancer, breast cancer, skin cancer, and other tumor cell lines.[15] Recent research has found that recombinant SLURP1 protein can activate the calcium signaling pathway in T cells,[16] suggesting that SLURP1 may play a role in regulating immune cell function. Here, SLURP1 is linked to colonic neoplasm.