Moreover, SLURP1 secreted by Salmonella resulted in significant tumor regression in a mouse CT26 tumor model, which indicates that SLURP1 might be a potential tumor suppressor in CRC.[27] The present study demonstrated that colon‐ cancer‐cell‐derived SLURP1 regulates the polarization state of TAMs, thereby enhancing antitumor response. Here, SLURP1 is linked to malignant colon neoplasm.