microRNA‐32533 (miR‐32533), a novel 23‐base sequence non‐coding RNA, improves Alzheimer's disease (AD)‐like cognitive impairment and inhibits amyloid‐β (Aβ) overload by regulating the beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1)‐involved amyloidogenic and α disintegrin and metalloproteinase 10 (ADAM10)‐involved non‐amyloidogenic pathways through its direct target cAMP‐responsive element binding protein 5 (CREB5) and downstream transcriptional machinery. This evidence concerns the gene CREB5 and early-onset autosomal dominant Alzheimer disease.