It is highly associated with gastrointestinal helminths (alongside IgE), due to the strong T helper (Th)‐2 immune response to clear the parasites; helminth infections trigger the production of cytokines including interleukin‐4, which is associated with class switching in B cells to produce IgG and IgE (Logan, Chetty, and Horsnell 2014). Here, IGHE is linked to helminthiasis.