IRF4 is known to be important for plasma cell survival and differentiation [62] and is also implicated in lymphoid malignancy development.[63] In B cells, loss of IRF4 is correlated with mitochondria elimination and disrupted lipid metabolism.[64] While IRF4 regulates lipolysis in adipocytes,[26, 36] a study on its role in tumor metabolism is still under investigation. The gene discussed is IRF4; the disease is neoplasm.