The specific objectives are to: identify and classify SNPs in the Bcl-2 gene and assess their pathogenic potential using bioinformatics and validated computational tools; analyze the structural and functional impacts of deleterious Bcl-2 mutations on protein-protein interactions (PPIs) and drug-binding characteristics; and pinpoint key mutations, such as Bcl-2G101V and Bcl-2F104L, that significantly affect protein behavior, offering valuable insights for cancer diagnostics and therapeutic strategies. Here, BCL2 is linked to cancer.