Additionally, GR interacts with coactivator molecules to suppress the expression of inflammatory genes by inhibiting the action of proinflammatory transcription factors such as NF-kB and activating protein 1 (AP-1) (149) to suppress the production and release of cytokines, proinflammatory chemokines, and airway epithelial cell adhesion molecules, which are crucial in the pathogenesis of asthma (150). This evidence concerns the gene FOS and asthma.