AKT1 and glioblastoma: The study also found that luteolin can significantly inhibit the migration of human glioblastoma cells, which is related to the downregulation of MMP-2 and MMP-9 and the upregulation of TIMP-1 and TIMP-2, and affects epithelial-mesenchymal transition and p-IGF-1R/PI3K/AKT/mTOR signaling pathway.