And a study in children with HSP showed that U-IgG (OR = 1.48; 95% CI: 1.23–1.85; p < 0.010) and U-TF (OR = 1.50; 95% CI: 1.17–2.22; p = 0.013) were significantly associated with progression of renal involvement (Liu et al., 2019). This evidence concerns the gene TF and hereditary spastic paraplegia.