PIK3C2A and acute kidney injury: Rhabdomyolysis syndrome refers to the destruction of the integrity of skeletal muscle cell membranes and the leakage of cell contents, including enzymes such as myoglobin and creatine phosphokinase (CPK), as well as toxic ions and small molecules into the blood, leading to a group of clinical syndromes often accompanied by life-threatening acute kidney injury when muscles are damaged by various factors.