ANGPTL4 and kidney disorder: Furthermore, serum ANGPTL4 levels positively correlate with clinical biomarkers of DKD (such as the urine albumin-to-creatinine ratio and serum creatinine) and negatively correlate with the estimated glomerular filtration rate (eGFR) (Al Shawaf et al., 2019), suggesting that circulating ANGPTL4 may serve as a biochemical marker for detecting renal disease status in diabetic patients.