In models of nephropathy induced by adriamycin or puromycin, as well as LPS-induced AKI, the inhibition of ANGPTL3 markedly reduces proteinuria, podocyte apoptosis, and renal functional impairment (Zhao et al., 2021; Ma Y. et al., 2022; Ji et al., 2023). The gene discussed is ANGPTL3; the disease is kidney disorder.