We observed significantly reduced methylation of interferon-regulated genes, including IFIT1, IFIT3, MX1, STAT1, IFI44L, USP18, TRIM22, and BST2, in naïve CD4+ T cells of lupus patients, indicating epigenetic transcriptional accessibility at these gene loci (Coit et al., 2013). This evidence concerns the gene USP18 and systemic lupus erythematosus.