SARS-CoV-2 may induce adipose tissue dysfunction, leading to adverse outcomes in acute COVID-19 (16), although some studies have shown unchanged or elevated APN levels (17), a majority of studies have reported decreased serum APN levels after COVID infection and agree in defining a clear role for APN in contributing to adverse outcomes in COVID-19 patients (18). The gene discussed is ANPEP; the disease is COVID-19.