Data integration revealed major clusters on the basis of marker genes, including CD8+ T cells (CD8A, GZMK), CD4+ T cells (IL7R, LTB), natural killer (NK) cells (GZMB, GNLY), B cells (IGKC, IGLC3), MCs (TPSAB1, TPSB2), macrophages (APOC1, APOE), monocytes (LST1, S100A8), DCs (CST3, NAPSB), endothelial cells (IGFBP5, FLT1), fibroblasts (RGS5) and tumor cells (CRYAB, NNMT) (Figures 1A, B; Supplementary Table S2). This evidence concerns the gene CD4 and neoplasm.