IL1B and nonpapillary renal cell carcinoma: The results revealed that cells in MC4 were closer to IL-1β+ macrophages than to other macrophages (Figures 5F; G), which further supported the existence of spatial colocalization of IL-1β+ macrophages with MC4, further supporting a potentially critical role for IL1β+ macrophages-MCs interactions at the interface of ccRCC (29–31): the presence of IL1β+ macrophages may drive the onset of MC heterogeneity in ccRCC, namely, the generation of MC4, which plays a protumor angiogenic role.