LAMP1 and acute respiratory distress syndrome: Our findings unveil the immunomodulatory effects of 1,25(OH)2D in alleviating trNK cell function via CD107a and NKp46 and phenotypic alteration through the assessment of crucial receptors, such as PD-1 and VDR on trNK cells that are important in defining the regulatory destination of lung trNK cells and consequently influencing the pathogenesis of ALI.