Moreover, Figure 8C displayed 20 crucial co-enriched pathways, encompassing immune and inflammation-related pathways such as Th17 cell differentiation, Th1 and Th2 cell differentiation, and NF-κB signaling pathway, cancer-related pathways like HCC and Ras signaling pathway, neurological diseases related pathways including SCA, PD, and pathways of neurodegeneration - multiple diseases, and diabetes and cardiovascular disease-related pathways such as insulin resistance (IR), type II diabetes mellitus, and diabetic cardiomyopathy. This evidence concerns the gene NFKB1 and type 2 diabetes mellitus.