Additionally, Stat2 is involved in lipid synthesis by regulating acetyl-CoA carboxylase 1 (ACC1) levels (39, 40), indicating that Stat2 may be a key transcription factor in the MoMFs subset involved in the alleviation of hepatic steatosis and inflammation in NAFLD by JQF. Here, STAT2 is linked to metabolic dysfunction-associated steatotic liver disease.