The following have been established: (1) brucellosis directly or indirectly invades the blood-brain barrier; (2) dysfunction of the blood-brain barrier; (3) activation of protein kinase pathways; (4) upregulation of innate immune receptors; and (5) demyelination of nerve cells and formation of ganglioside antibodies (14). This evidence concerns the gene WEE1 and brucellosis.