CD274 and gastric cancer: TAMs expressing IL-10 are associated with CD8+ T-cell dysfunction, as well as features of gastric cancer such as the Epstein–Barr virus status, programmed death ligand-1 (PD-L1) expression, and genomic stability, underscoring the importance of TAMs as potential prognostic biomarkers for gastric cancer and their role in promoting immune evasion through IL-10 production (92).