For example, administer solely an irradiated, granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting, allogeneic vaccine known as GVAX to patients suffering from pancreatic ductal adenocarcinoma (PDAC), allowing the vaccine antigen to be more effectively absorbed by immune cells within TLSs. The gene discussed is CSF2; the disease is pancreatic ductal adenocarcinoma.