In the current study, using the eCRSwNP murine model (24), we found that the levels of eotaxin and type 2 cytokines, including IL-4, IL-5, and IL-13, in local tissues and nasal lavage fluid were lower in Gαi1 and Gαi3 DKO mice, compare those in the CRS group. This evidence concerns the gene IL5 and congenital rubella syndrome.