IGHE and congenital rubella syndrome: In addition, we found that the CRS group produced a large amount of serum IgE (2,045.57 ± 974.12 vs. 4.39 ± 4.56, p < 0.0001) and OVA-specific IgE (391.85 ± 152.48 vs. 0.01 ± 0.02, p < 0.0001, Figure 8C) compare to control group.