In future studies, we will conduct differentiation experiments of bone marrow-derived eosinophils (BMDE) using DKO and WT mice, and analyze the populations of eosinophils and eosinophil progenitors in the bone marrow of CRS models through flow cytometry, to further elucidate the relationship between Gαi1/3 and IL-5Rα in eosinophilia. The gene discussed is IL5RA; the disease is congenital rubella syndrome.