AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: ICT activates NF-related apoptosis-inducing ligand, Fas-caspase-3/8 (69, 70), inhibits the phosphorylation of Akt and mTOR (71, 72), activates PTEN/Parkin-dependent mitochondrial autophagy (73), downregulates Jak-2, p-Stat3, and p-Akt expression (74), and upregulates p-JNK and p-C-Jun expression (75, 76), thereby inducing apoptosis in human glioblastoma, liver cancer, ovarian cancer, and chronic myeloid leukemia cells.