Galectin-3 expression is typically elevated and considered a marker for tumor progression and metastasis, as it is involved in various processes such as cell adhesion, migration, invasion, angiogenesis, and immune suppression, often promoting cancer cell growth and spread across different tissues; essentially, high galectin-3 expression is associated with a poorer prognosis in many cancers (68). This evidence concerns the gene LGALS3 and cancer.