NFKB1 and acute respiratory distress syndrome: For instance, overexpressing hsa-let-7i-5p in exosomes from human placenta-derived MSCs can reduce M1 polarization and pro-inflammatory cytokine release, along with inactivation of NF-κB and HIF-1α, alleviating tissue edema and leukocyte infiltration in sepsis-induced ALI (73).