Curcumin, found in turmeric, is a hydrophobic polyphenol that has been shown to exert an anticancer effect through a reversal of p53 and Pten, attenuation of anti-apoptotic genes (e.g., OX-2, NF-κB, and Bcl-2) and regulation of the TME in favor of tumor suppression through inhibition of IL-10, TGF-β, CAFs, and TAMs (159). This evidence concerns the gene PTEN and neoplasm.