AKT1 and gingival cancer: Potential antitumor drugs like chlorpromazine have also been found to induce autophagy in gingival cancer cells by upregulating autophagy-related proteins (Atg5, Atg7, Atg12, Beclin-1, and LC3A/B-II) while downregulating negative regulators (mTOR, PI3K, Akt, and p70S6K) (26–28).