The overlapping clinical and genetic spectrum of ALS and FTD is reflected in their shared pathology: TDP-43-positive neuronal inclusions are a hallmark feature of both diseases, reinforcing their classification as part of the TDP-43 proteinopathy continuum (Gao et al., 2018; Tan et al., 2017). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.