MAPT and Mental deterioration: This chronic, progressive neurodegenerative disorder is characterized by cognitive decline and memory loss, primary driven by hallmark neuropathological features: extracellular amyloid-β plaques (Glenner and Wong, 1984; Hardy and Higgins, 1992; Hardy and Allsop, 1991; Masters et al., 1985; Selkoe, 1991; Selkoe and Hardy, 2016) and tau neurofibrillary tangles (Goedert et al., 1991; Kosik et al., 1986) in the brain, resulting in neuronal and synaptic loss (Serrano-Pozo et al., 2011).