Since ACE-2/ angiotensin (Agostini et al., 2019; Agostini et al., 2017; Bourgade et al., 2016; dos Santos Picanco et al., 2018; Breijyeh and Karaman, 2020; Kumar et al., 2015; Mawanda and Wallace, 2013)/Mas axis has neuroprotective functions, ACE-2 depletion can increase the risk of NDs development including AD (Ni et al., 2020). The gene discussed is ACE2; the disease is Alzheimer disease.