SARS-CoV-2 infection can trigger a severe immune response known as a cytokine storm, leading to widespread inflammation in the brain. This inflammation activates microglia and astrocytes, which can increase Aβ production and deposition.The infection induces oxidative stress, which can further promote the aggregation of Aβ and tau proteins.SARS-CoV-2 proteins may directly interact with neuronal cells, potentially influencing the production and aggregation of Aβ.SARS-CoV-2-related neuroinflammation and Aβ deposition are often observed in the hippocampus. The frontal cortex can also be affected. The gene discussed is MAPT; the disease is infection.