This cellular and molecular heterogeneity contributes to measurable relaxometry differences in peritumoral white matter, offering a potential diagnostic marker.40–43 Another study by springer et al.31 reported that MRF demonstrated significant differences in MRF derived T1 and T2 values were observed between IDH-mutant and IDH-wild type gliomas, particularly in solid tumor regions. This evidence concerns the gene IDH1 and glioma.