Wang N et al. evaluated the lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-lymphocyte ratio (ELR), basophil-to-lymphocyte ratio (BLR), platelet-to-lymphocyte ratio (PLR), as well as the HALP, the predictive value of these indicators and constructed predictive models, and found that the inclusion of HALP individually further enhanced the predictive efficacy in the study of acute exacerbations of chronic obstructive pulmonary disease (24). The gene discussed is NAT10; the disease is chronic obstructive pulmonary disease.