VEGFC and cholangiocarcinoma: When investigating the levels of eNOS and phosphorylated eNOS (P-eNOS), together with the regulators VEGFR3, VEGFC, EphA3 and ephrin1, in a hamster model of induced CCA and human CCA, it was seen that in the latter intense immunohistochemical staining of all examined proteins was associated with metastasis.