EPHA1 and cancer: Numerous studies have demonstrated the role of the Eph/ephrin system in a variety of cancers, including carcinoma from the gastrointestinal tract (12–14), colon (15, 16), pancreas (17), esophagus (18, 19), liver (20), prostate (21, 22), lung (23, 24), thyroid (25), breast (26, 27), ovaries (28), and others.