In summary, most Eph receptors (EphA1, EphA2, EphA3, EphA4, EphA5, and EphA7) function as promoters of GC progression, influencing metastasis, tumor invasion, angiogenesis, and drug resistance, while EphA1 has a more complex role depending on tumor differentiation. This evidence concerns the gene EPHA4 and neoplasm.