Beyond its role in tolerating cancer treatment-induced damage like cisPt-GG adducts and Tg lesions, Pol ζ is proficient in TLS extension in human cells when challenged with abasic sites, benzo[SB ITAL a]pyrene-guanine (BP-G) and 4-hydroxyequilenin-C (4-OHEN-C) lesions, and thymine-thymine 6-4 photoproducts (TT 6-4 PP) (155). This evidence concerns the gene REV3L and cancer.